Integrating Implementation Outcomes into Effectiveness Studies: A Practical Guide for Clinical Interventionists

Designing effectiveness studies with implementation in mind can allow interventionists to translate their research into real-world practice. Implementation outcomes measure how much and how well a particular intervention was implemented and can provide valuable insights into any heterogeneity in effectiveness outcomes. As part of the National Institutes of Health’s (NIH) Helping to End Addiction Long-term®…

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From Glitter to Gold: Recommendations for Effective Dashboards from Design through Sustainment

Implementation Science journal cover

Dashboards—tools that compile and summarize key performance data—have become increasingly utilized for supporting data organization and decision-making processes across various fields, such as business, economics, healthcare, and policy. The dashboard’s impact is dependent on its use by the individuals for whom it was designed. Yet, few studies measure dashboard use, and of those that do,…

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Using the IFASIS (Inventory of Factors Affecting Successful Implementation and Sustainment) to Advance Context-Specific and Generalizable Knowledge of Implementation Determinants: Case Study of a Digital Contingency Management Platform

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Background: Contingency management (CM) is the most effective treatment for stimulant use disorder but is underutilized by opioid treatment programs (OTPs) despite the high prevalence of stimulant use in this setting. As part of a state-wide initiative, we piloted a novel assessment, the Inventory of Factors Affecting Successful Implementation and Sustainment (IFASIS), to examine determinants…

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A Pragmatic Measure of Context at the Organizational Level: The Inventory of Factors Affecting Successful Implementation and Sustainment (IFASIS)

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Background: Successful implementation and sustainment of interventions is heavily influenced by context. Yet the complexity and dynamic nature of context make it challenging to connect and translate findings across implementation efforts. Existing methods to assess context are typically qualitative, limiting potential replicability and utility. Existing quantitative measures and the siloed nature of implementation efforts limit…

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Systemic Barriers and Stigma: Healthcare Provider Perspectives on Perinatal and Neonatal Care in the Fentanyl Crisis

The rise in fentanyl use during pregnancy has introduced new and complex challenges in caring for women with opioid use disorders (OUD) and their infants diagnosed with neonatal abstinence syndrome or neonatal opioid withdrawal syndrome (NAS/NOWS). Despite the increasing prevalence of opioid-affected mother-infant dyads, limited research exists on healthcare providers’ perspectives regarding fentanyl’s impact on…

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Understanding Inequitable Healthcare: Methodological Approaches, Challenges, and Opportunities

This paper considers methodological approaches that can help better understand inequity in healthcare, focusing on five key domains: availability, patient-centeredness, access, effectiveness, and implementation. We present conceptual definitions of each of these domains, example research questions pertaining to inequity in each domain, and methodological approaches that can contribute to research about health inequities. We discuss…

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Rollout Trial Designs in Implementation Research are Often Necessary and Sometimes Preferred

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Background: Rollout designs, which include stepped wedge designs, are defined by staggered implementation of new or alternative programs or services. Critiques of stepped wedge and other rollout designs have raised concerns regarding the confounding of true implementation or program effects with unrelated, global changes in service delivery, with some recommending they only be used when…

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The Difference-Making Role of Staff Support in Implementing Nurse Care Management for Opioid Use Disorder Treatment: A Configurational Analysis.

Introduction: Understanding conditions in which interventions succeed or fail is critical. The PRimary care Opioid Use Disorders treatment (PROUD) trial, a cluster-randomized hybrid study, tested whether implementation of office-based addiction treatment supported by a nurse increased medication of OUD. Six health systems each provided two primary care (PC) clinics that were randomly assigned to implement…

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A Framework for Designing Hybrid Effectiveness-Implementation Trials for Digital Health Interventions

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This article proposes methods for designing randomized controlled trials studying the implementation and effectiveness of digital interventions, meaning websites or applications (“apps”) that patients use in healthcare. Deploying digital interventions for behavioral health differs from implementing traditional interventions such as medications or human-delivered therapy. Prior trial design guidance has ignored the existence of international governmental…

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Effectiveness of Mutual Health Groups for Illicit Drug Use Disorders: A Review of the Current Literature

Purpose of Review: Evaluate literature examining whether mutual help groups (MHGs) for illicit drug use disorders benefit participants. Recent Findings: Recent studies consistently show that MHG attendance and involvement predict reductions in drug use and addiction severity. More rigorous methodologies offer stronger evidence of effectiveness, but additional controlled trials are needed. Drug-focused MHG challenges include…

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